Working computationally in applied mathematics is the very essence of dealing with real-world problems in science and engineering. Approximation theory-on the borderline between pure and applied mathematics- has always supplied some of the most innovative ideas, computational methods, and original approaches to many types of problems. The first of its kind, the Handbook on Analytic-Computational Methods in Applied Mathematics comprises 22 self-contained chapters focused on various aspects of analytic computational methods in approximation theory and other related fields. The articles represent the leading research activities of contemporary, mainstream applied mathematics and address problems in a broad range of disciplines, from economics to statistics, dynamic programming, and engineering.