This second edition of a successful title bridging toxicology and environmental chemistry adopts a unique approach that ‘follows’ chemicals on a molecular level, from the environment through the different uptake mechanisms into the body, to the toxic effect. Along the way, this textbook explains the different routes of degradation and metabolism of the different classes of chemicals, linking general chemical properties to their toxicological equivalents. All the chapters have been thoroughly updated and the contents significantly expanded, including for example new chapters on pesticides, food chemicals and pharmaceuticals, as well as sections discussing endocrine disruptors and carcinogenicity assays. This is an essential text for a wide audience ranging from pharmacologists to environmental chemists and toxicologists.