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170104s2017 enk o 001 0 eng d |
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|a9780128037126 (electronic bk.)
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|a0128037121 (electronic bk.)
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|a9780128036907
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|a0128036907
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|aYDX|beng|epn|cYDX|dN$T|dIDEBK|dEBLCP|dOPELS|dN$T|dOCLCF|dOCLCQ|dUPM|dOCLCQ|dCOO|dOCLCO|dMERER|dOCLCQ|dOTZ|dOCLCQ|dOCLCA|dD6H|dDKU|dU3W|dCNCGM|dZ5A|dCASUM|dUAB|dLVT|dAU@|dOCLCO|dOCLCQ|dOCLCO|dS2H|dOCLCO|dOCLCA
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|aeng
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|aRC523
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|a2017 D-046
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|aWT 155
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|a616.8/311|223
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|aNF|tLCC|p|dRC523|e|c
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|aNeuroprotection in Alzheimer's disease|h[electronic resource] /|cedited by Illana Gozes.
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|aLondon, United Kingdom :|bAcademic Press,|c2017.
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|a1 online resource
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|aCover; Title page; Copyright Page; Dedication; Contents; List of Contributors; Acknowledgments; Chapter 1 -- Introduction; Chapter 2 -- Neural Regeneration as a Disease-Modifying Therapeutic Strategy for Alzheimer's Disease; Introduction; Global health care burden of Alzheimer's disease: epidemiological data; Etiopathogenesis of Alzheimer's disease: what do we know?; Therapeutic approaches to Alzheimer's disease: the promises, the failures, and the future; Neural regeneration-based therapeutic approach for AD: the rationale, the promise, and the progress.
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|aNeurotrophic factor small-molecule mimetics for Alzheimer's diseaseEnhancement of neurogenesis and memory by CNTF small-molecule mimetics; CNTF-derived neurogenic/neurotrophic compound, P021, can exert a disease-modifying effect in a transgenic mouse model of AD; Summary and conclusions; References; Chapter 3 -- Animal Models of Alzheimer's Disease; Introduction; The genetics of Alzheimer's disease; Transgenic models of amyloidogenesis; Amyloid precursor protein transgenic mice; PDAPP transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tg2576 transgenic mice; Histopathology.
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|aBehaviorSynaptic Plasticity; APP23 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; J20 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP knock-in transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP/PS1 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; 5xFAD transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tau transgenic mice; Tau tg mice under tau promoter; Histopathology; Behavior; Synaptic Plasticity; 3xTg transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Animal models for late onset of AD.
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|aApoE Transgenic MiceApoE Knock-Out Transgenic Mice; ApoE2/ApoE3/ApoE4 Knock-In Transgenic Mice; GFAP-ApoE4/ApoE Knock-Out Transgenic Mice; ApoE/APP Transgenic Mice; Nonmouse models; Studies in nematodes; Studies in fruit flies; Nontransgenic models for the study of AD; How to choose the right model?; Summary; Acknowledgment; References; Chapter 4 -- Mechanisms of Neuronal Microtubule Loss in Alzheimer's Disease; Introduction; Studies on Alzheimer's brain and animal models; Are microtubules destabilized in the Alzheimer's brain?; Mechanisms of microtubule loss in the Alzheimer's brain.
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|aStrategies for treatmentAcknowledgments; References; Chapter 5 -- Tau-Centric Therapies for Treating Alzheimer's Disease; Introduction; Six Tau Isoforms-Many Tau Functions; Mechanisms of Tau Toxicity: Phosphorylation, Microtubule Destabilization, and Aggregation; Tau-centric therapeutic strategy 1: targeting tau phosphorylation; Tau Phosphorylation in Physiological and Pathological States; Mechanisms for Stimulating Tau Phosphorylation; Consequences of Phosphorylation; Therapeutic Strategies to Inhibit Tau Phosphorylation; Current State of Affairs.
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|aAlzheimer's disease.
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|aAlzheimer's disease|xPrevention.
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|aAlzheimer Disease|xprevention & control.
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|aNeuroprotection.
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|aHEALTH & FITNESS|xDiseases|xGeneral.|2bisacsh
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|aMEDICAL|xClinical Medicine.|2bisacsh
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|aMEDICAL|xDiseases.|2bisacsh
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|aMEDICAL|xEvidence-Based Medicine.|2bisacsh
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|aMEDICAL|xInternal Medicine.|2bisacsh
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|aAlzheimer's disease.|2fast|0(OCoLC)fst00806532
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7
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|aAlzheimer's disease|xPrevention.|2fast|0(OCoLC)fst00806584
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0
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|aComputer network resources.
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4
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|aFulltext.
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4
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|aInternet Resources.
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|aGozes, Illana,|eeditor.
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|uhttps://www.sciencedirect.com/science/book/9780128036907
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